巨大結腸症

http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/article/view/62/1614 

 

 

写真は、巨大結腸症の手術例です。


この写真とは、関係ありませんが、

便秘の治療のために、高FODMAPのラクツロースを服用し、

大量のガスによって巨大結腸症を引き起こし、死亡したという報告があります。

 

Ned Tijdschr Geneeskd. 2004 May 15;148(20):998-1001.

Megacolon during treatment with lactulose

van der Vliet HJvan Bodegraven AA.

Abstract

Two female patients aged 88 and 82 who were being treated for constipation with lactulose, developed life-threatening dilatation of the bowel. Both underwent surgery. One of them was found to have cancer of the bowel; she had an uneventful postoperative recovery. No mechanical abnormalities were found in the second patient but she died due to respiratory insufficiency following aspiration. Lactulose is one of the most frequently prescribed laxatives. In the colon it is metabolized by bacteria into short-chain fatty acids, hydrogen and carbon dioxide. The resulting production of gas in the colon can contribute to a non-toxic megacolon, particularly in patients with delayed intestinal passage.