Gas and water will increase in the intestinal tract by a high-FODMAP.

Thereby, it will cause the symptoms of irritable bowel syndrome.

However, the black box exists.

I was reported to the introducer method of percutaneous endoscopic cecostomy. It was the first time report in the world.

I experienced the 100 of cecostomy patients.

Even if the injection of water 1 L from cecostomy in order to antegrade continence enema; the patients did not occur IBS symptom.
 

Why increasing of gas and water is lead to IBS symptoms?

What are the mechanisms that produce an alternating bowel movement abnormality?

In the black box, the physiological factors of the intestinal tract might be contains.