Office Uno column: Yoshiharu Uno, Ph.D.

PPI cycle develops to form a spiral by the elements of time.

The pH of the stomach rises with the passage of time.

SIBO might occur by increasing of gastric pH.

By unfavorable meal in the digestive tract, risk of further SIBO will be higher.

(High gastric pH) + (High FODMAP diet; HFD) = High risk of SIBO

This relationship is double helix structure.



 

Many of the disease will occur by the progress of the double structure of internal factors and external factors.